Endocrine Abstracts

The use of Sandostatin analogues for the treatment of acromegaly is now widely accepted practice for use as an effective method of reducing growth hormone levels to normal, either as primary therapy or prior to or post surgery.An audit was carried out on 11 patients who had been commenced on monthly depot injections of Sandostatin LAR over a 12 month period. Patients notes were used to obtain information regarding, date of diagnosis, presenting features/...

ObjectiveTo investigate whether salivary cortisol could provide an alternative to serum cortisol for hypocortisolaemic patients undergoing hydrocortisone day curves.MethodCorrelational study of 58 patients receiving corticosteroid replacement therapy for primary (9) or secondary (49) hypocortisolaemia. Paired samples of saliva and serum were taken at pre-determined time points throughout a 7½ hour hydroc...

Summary: Physiological replacement of glucocorticoids in hypocortisolemic patients remains a challenge. We assessed the use of salivary cortisol and total serum cortisol profile with CBG measurement in monitoring glucocorticoid replacement in hypoadrenal patients in routine clinical practice.Methods: Serum and salivary cortisol concentrations were measured in 60 hypoadrenal patients previously documented to have cortisol deficiency on provocative testing...